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Super-enhancer formation in scirrhous gastric cancer-associated fibroblasts, and its presence in fibroblasts in non-cancerous tissues (2)

GSE322674 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/06/10 Platform GPL30173
Summary
Scirrhous gastric cancer has aggressive clinical courses and is characterized by dominating cancer-associated fibroblasts (CAFs). We here aimed to explore the molecular basis for scirrhous CAFs and their origin. Scirrhous CAFs had heavily acetylated super-enhancers, and therapeutic targeting of super-enhancers by a BET bromodomain inhibitor, mivebresib, markedly decreased their migration-promoting activity.
Published in
Super-Enhancer Formation in Scirrhous Gastric CAFs, and the Presence of a Stromal Field in Non-Cancerous Tissues
Yasukawa Y, Hattori N, Liu YY et al. · Cancer science 2026 · PMID 42070972 · doi:10.1111/cas.70408
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Also filed as BioProject PRJNA1430894 and SRA study SRP680432. Searching any of these in the dataset finder brings you back here.

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