Maternal Hyperhomocysteinemia Compromises Female Offspring Fertility Through Over-Activation of Primordial Follicles
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Maternal hyperhomocysteinemia compromises female offspring fertility through overactivation of primordial folliclesiScience · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE322825_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1431926 and SRA study SRP680876. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9560081 F1-HHcyPD3_1 F1-HHcyPD3
- GSM9560082 F1-HHcyPD3_2 F1-HHcyPD3
- GSM9560083 F1-HHcyPD3_3 F1-HHcyPD3
- GSM9560084 F1-HHcyPD7_1 F1-HHcyPD7
- GSM9560085 F1-HHcyPD7_2 F1-HHcyPD7
- GSM9560086 F1-HHcyPD7_3 F1-HHcyPD7
- GSM9560087 F1-HHcyPD21_1 F1-HHcyPD21
- GSM9560088 F1-HHcyPD21_2 F1-HHcyPD21
- GSM9560089 F1-HHcyPD21_3 F1-HHcyPD21
- GSM9560090 F1-ControlPD3_1 F1-ControlPD3
- GSM9560091 F1-ControlPD3_2 F1-ControlPD3
- GSM9560092 F1-ControlPD3_3 F1-ControlPD3
- GSM9560093 F1-ControlPD7_1 F1-ControlPD7
- GSM9560094 F1-ControlPD7_2 F1-ControlPD7
- GSM9560095 F1-ControlPD7_3 F1-ControlPD7
- GSM9560096 F1-ControlPD21_1 F1-ControlPD21
- GSM9560097 F1-ControlPD21_2 F1-ControlPD21
- GSM9560098 F1-ControlPD21_3 F1-ControlPD21
- GSE287234 Intrauterine hyperglycemia impairs primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference in mice offspring [RNA-seq] 36 samples shares primordial, offspring, fertility
- GSE263843 Theophylline derivatives promote the activation of primordial follicles and ameliorate fertility deficits in naturally aged mice 6 samples shares primordial, fertility, follicles
- GSE286574 Intrauterine hyperglycemia impairs primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference in mice offspring [ATAC-seq] 30 samples shares primordial, offspring, fertility
- GSE290574 Gene Regulatory Networks Orchestrating Oocyte Fate Bifurcation in Primordial Follicles Revealed by Single-Cell Transcriptomics 386 samples shares primordial, follicles
- GSE40716 Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice 12 samples shares primordial, offspring
- GSE255212 Transcriptomic Signatures of WNT-Driven Pathways and Granulosa Cell-Oocyte Interaction during Primordial Follicle Activation 762 samples shares primordial
- GSE289335 TRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration [bulkRNA-seq, scRNA-seq] 127 samples shares primordial
- GSE248233 Chronic alcohol drinking compromises lung immunity by altering immunometabolism in both human and mouse lungs 42 samples shares compromises
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.