MEF2C controls lysosomal and lipid clearance programs linked to Alzheimer’s disease risk in macrophages [ATAC-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 8 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 8 samples: 8 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- MEF2C controls lysosomal and lipid clearance programs linked to Alzheimer's disease risk in macrophagesResearch square · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE323981_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1432878 and SRA study SRP681241. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 8 sample titles: 8 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9566044 MEF2C-KO, non-treated, differentiation 1, clone D8 (ATAC-seq)
- GSM9566045 MEF2C-KO, non-treated, differentiation 1, clone G2 (ATAC-seq)
- GSM9566046 MEF2C-KO, non-treated, differentiation 1, clone H11 (ATAC-seq)
- GSM9566047 MEF2C-KO, non-treated, differentiation 1, clone D9 (ATAC-seq)
- GSM9566048 WT, non-treated, differentiation 1, clone F2 (ATAC-seq)
- GSM9566049 WT, non-treated, differentiation 1, clone C2 (ATAC-seq)
- GSM9566050 WT, non-treated, differentiation 1, clone E2 (ATAC-seq)
- GSM9566051 WT, non-treated, differentiation 1, clone H2 (ATAC-seq)
- GSE323984 MEF2C controls lysosomal and lipid clearance programs linked to Alzheimer’s disease risk in macrophages [bulkRNAseq_WTC11_iMGL] 48 samples shares mef2c, macrophages, lysosomal, clearance, alzheimer, controls, programs
- GSE323982 MEF2C controls lysosomal and lipid clearance programs linked to Alzheimer’s disease risk in macrophagesm [scRNAseq_WTC11_iMGL_ReN] 16 samples shares mef2c, macrophages, lysosomal, clearance, alzheimer, controls, programs
- GSE294915 IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itself [ATAC-Seq] 22 samples shares macrophages, atac-seq
- GSE263079 Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease [dataset3] 32 samples shares clearance, alzheimer
- GSE306993 Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease. 76 samples shares mef2c
- GSE270436 Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease 21 samples shares mef2c
- GSE307817 A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease 12 samples shares mef2c
- GSE307329 Continuous NRTI-based antiretroviral therapy induces progressive senescence-like reprogramming of alveolar macrophages [ChIP-seq] 74 samples shares macrophages
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.