GEO series
HIF-1α and HIF-2α regulate overlapping and distinct transcriptional programs in primary human T cells [RNA-Seq]
GSE324038
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2026/04/01
GPL24676
Summary
Hypoxia-inducible factor 2α (HIF-2α) is a central oncogenic driver in clear cell renal cell carcinoma (ccRCC). Here, we investigated the cell-intrinsic effects of HIF-2α perturbation in primary human T cells. CRISPR/Cas9-mediated deletion of HIF-2α downregulated transcriptional programs associated with T cell effector function.
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