GEO series
Lactylation Converts ABHD6 into a Mitochondrial Regulator that Drives Lenvatinib Resistance in Hepatocellular Carcinoma
GSE324183
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/03/13
GPL34284
Summary
Hepatocellular carcinoma (HCC) frequently develops resistance to lenvatinib, a frontline tyrosine kinase inhibitor. Resistance arises from heterogeneous mechanisms involving metabolic reprogramming and mitochondrial adaptation, implicating regulators of these processes as potential therapeutic targets.
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Paper (PMID 41861279) ↗
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