GEO series
Bioinspired, Mitochondria-targeted Single-atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism
GSE324502
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2026/03/16
GPL24247
Summary
A bioinspired nanozyme—TPP-DMSN-Fe/Cu—mimics mitochondrial complex IV and targets mitochondria to regulate cellular energy metabolism. This approach markedly boosts bone regeneration in vivo, as demonstrated by enhanced bone volume and mineral density in critical-sized bone defects rat models. The study opens new avenues for mitochondria-targeted therapies in bone repair.
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Paper (PMID 41944648) ↗
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