Elongin B orchestrates chromatin and transcriptional programs in H3K27M‑mutant diffuse midline glioma [XIII_K27MKO_CUTandRUN]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 10 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 10 samples: 2 × XIII_CTL2_K27M vs 2 × XIII_K27MKO_K27M vs 2 × XIII_CTL2_IgG vs 2 × XIII_K27MKO_IgGGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE324873_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1438030 and SRA study SRP684004. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 4 replicated groups read from 10 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9588134 XIII_CTL2_K27Mrep1 XIII_CTL2_K27M
- GSM9588135 XIII_CTL2_K27Mrep2 XIII_CTL2_K27M
- GSM9588136 XIII_K27MKO_K27Mrep1 XIII_K27MKO_K27M
- GSM9588137 XIII_K27MKO_K27Mrep2 XIII_K27MKO_K27M
- GSM9588138 XIII_CTL2_K27me3
- GSM9588139 XIII_K27MKO_K27me3
- GSM9588140 XIII_CTL2_IgGrep1 XIII_CTL2_IgG
- GSM9588141 XIII_CTL2_IgGrep2 XIII_CTL2_IgG
- GSM9588142 XIII_K27MKO_IgGrep1 XIII_K27MKO_IgG
- GSM9588143 XIII_K27MKO_IgGrep2 XIII_K27MKO_IgG
- GSE324878 Elongin B orchestrates chromatin and transcriptional programs in H3K27M‑mutant diffuse midline glioma [XIII_ELOB_CUTandRUN] 21 samples shares h3k27m, xiii, orchestrates, chromatin, cutandrun, programs, elongin
- GSE324875 Elongin B orchestrates chromatin and transcriptional programs in H3K27M‑mutant diffuse midline glioma [XIII_ELOBKO_chIP_ELOB_RNAPII] 10 samples shares h3k27m, xiii, orchestrates, chromatin, programs, elongin
- GSE324874 Elongin B orchestrates chromatin and transcriptional programs in H3K27M‑mutant diffuse midline glioma [XIII_ELOBKO_RNAseq] 12 samples shares h3k27m, xiii, orchestrates, chromatin, programs, elongin
- GSE205248 H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs [scRNA-seq] 11 samples shares h3k27m, chromatin, programs
- GSE312029 Spatiotemporal remodeling of chromatin topology architecture and H3K27me3 redistribution underlies vascular pathology in Hutchinson-Gilford progeria syndrome [CUT&Tag] 84 samples shares h3k27m, chromatin
- GSE294323 Thyroid cancer-associated EZH1 Q571R mutation drives chromatin compaction and H3K27me3 invasion into active chromatin 18 samples shares h3k27m, chromatin
- GSE294321 Thyroid cancer-associated EZH1 Q571R mutation drives chromatin compaction and H3K27me3 invasion into active chromatin 16 samples shares h3k27m, chromatin
- GSE280616 H3K27me3 chromatin heterogeneity reveals variable cell responses to estrogen and endocrine treatment [CUT&Tag] 16 samples shares h3k27m, chromatin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.