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Single-cell RNA sequencing of chondrocytes from osteoarthritis (OA) patients and healthy controls

GSE324993 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/18 Platform GPL24676
Summary
Osteoarthritis (OA) is a common degenerative joint disease characterized by progressive cartilage degeneration and osteophyte formation. However, the mechanisms underlying OA progression remain poorly understood. Single-cell RNA sequencing (scRNA-seq) was performed on chondrocytes from three OA patients undergoing total knee arthroplasty and three control donors undergoing arthroscopic surgery for anterior cruciate ligament (ACL) injury to explore cellular heterogeneity and dysregulated pathways. These data provide a resource for investigating the molecular mechanisms underlying OA progression.
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Direct links to NCBI, no account and no request form: the whole study as GSE324993_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1437490 and SRA study SRP683704. Searching any of these in the dataset finder brings you back here.

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