GEO series
Hepatocytes promote liver metastasis of pancreatic cancer by providing exogenous serine, 2.
GSE324997
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2026/07/28
GPL24247
Summary
The liver is the major site of metastasis for pancreatic ductal adenocarcinoma (PDAC). In this work, we describe a mechanism wherein serine sythensis is essential for PDAC liver metastasis. To describe this, we knocked out Phgdh in mouse KPC cells and then co-cultured the cells with mouse hepatocytes.
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