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SLC1A5 prevents aortic aneurysm and dissection by glutaminolytic-epigenetic orchestration of vascular smooth muscle cell homeostasis [CUT&Tag]

GSE325132 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2026/03/17 Platform GPL34290
Summary
In this study, we found that H3K9ac level were reduced both in vitro (Slc1a5 knockdown VSMCs) and in vivo (Slc1a5 knockout mice). To further investigate the potential functional significance that SLC1A5-mediated H3K9ac contributed to the pathogenesis of aortic aneurysm and dissection (AAD), we performed genome-wide cleavage under targets and tagmentation (CUT&Tag) analysis to identify candidate genes regulated by H3K9ac (CST, 9649S) in Slc1a5 knockdown mouse VSMCs. Following CUT&Tag, H3K9ac associated DNAs were amplified using non-biased conditions, labeled, and sequenced with Illumina novaseq Xplus.
Published in
SLC1A5 prevents aortic aneurysm and dissection by glutaminolytic-epigenetic orchestration of vascular smooth muscle cell homeostasis
Yang P, Gao Z, Ye W et al. · Nature communications 2026 · PMID 41986354 · doi:10.1038/s41467-026-71856-4
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Also filed as BioProject PRJNA1438686 and SRA study SRP684519. Searching any of these in the dataset finder brings you back here.

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