Dietary supplementation with ursolic acid preserves skeletal muscle mass and strength in mouse models of cancer cachexia [RNA-seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × Tibialis anterior muscle, Sham, non-tumor bearing, vs 4 × Tibialis anterior muscle, KPC tumor-bearing, vs 4 × Tibialis anterior muscle, KPC tumor-bearing + ursolic acid,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Dietary supplementation with ursolic acid preserves skeletal muscle mass and strength in mouse models of cancer cachexiaAmerican journal of physiology. Cell physiology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE325158_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1438730 and SRA study SRP684551. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9596850 Tibialis anterior muscle, Sham, non-tumor bearing, rep1 Tibialis anterior muscl…
- GSM9596851 Tibialis anterior muscle, Sham, non-tumor bearing, rep2 Tibialis anterior muscl…
- GSM9596852 Tibialis anterior muscle, Sham, non-tumor bearing, rep3 Tibialis anterior muscl…
- GSM9596853 Tibialis anterior muscle, Sham, non-tumor bearing, rep4 Tibialis anterior muscl…
- GSM9596854 Tibialis anterior muscle, KPC tumor-bearing, rep1 Tibialis anterior muscl…
- GSM9596855 Tibialis anterior muscle, KPC tumor-bearing, rep2 Tibialis anterior muscl…
- GSM9596856 Tibialis anterior muscle, KPC tumor-bearing, rep3 Tibialis anterior muscl…
- GSM9596857 Tibialis anterior muscle, KPC tumor-bearing, rep4 Tibialis anterior muscl…
- GSM9596858 Tibialis anterior muscle, KPC tumor-bearing + ursolic acid, rep1 Tibialis anterior muscl…
- GSM9596859 Tibialis anterior muscle, KPC tumor-bearing + ursolic acid, rep2 Tibialis anterior muscl…
- GSM9596860 Tibialis anterior muscle, KPC tumor-bearing + ursolic acid, rep3 Tibialis anterior muscl…
- GSM9596861 Tibialis anterior muscle, KPC tumor-bearing + ursolic acid, rep4 Tibialis anterior muscl…
- GSE273878 Cancer-induced FOXP1 disrupts and reprograms skeletal muscle circadian transcription in cachexia [circadian RNA-seq] 48 samples shares skeletal, cachexia, rna-seq
- GSE280699 The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age [RNA-seq] 78 samples shares skeletal, rna-seq
- GSE308174 Bulk mRNA-seq analysis of mouse skeletal muscle, heart and liver expressing wild-type and mutant H2B 75 samples shares skeletal, rna-seq
- GSE266918 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [heart] 63 samples shares skeletal, rna-seq
- GSE266923 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [liver] 61 samples shares skeletal, rna-seq
- GSE266920 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [Adipose] 61 samples shares skeletal, rna-seq
- GSE325832 RNA-seq analysis of skeletal muscle from control (Cre) and Terf2 knockout (KO) mice in gastrocnemius-plantaris-soleus (GPS) and tibialis anterior (TA) 35 samples shares skeletal, rna-seq
- GSE262881 A single-cell transcriptomic atlas of all cell types in the entire 5xFAD mouse brain in response to dietary inulin supplementation 24 samples shares supplementation, dietary
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.