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Residual p53 in HPV positive cervical cancer cells has gain of function properties

GSE325258 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/13 Platform GPL24676
Summary
Human papillomavirus (HPV)-positive cervical cancer cells retain residual p53 despite E6-mediated degradation. To investigate whether this residual p53 has gain-of-function properties, CRISPR/Cas9 was used to generate p53 knockout HeLa clones and compare them with a WT control clone. RNA-seq profiling identified transcriptomic changes associated with loss of residual p53.
Published in
Rethinking residual p53 function in HPV-positive cervical cancer cells
Farrukh S, Kavcic N, Canarutto G et al. · Journal of virology 2026 · PMID 42200670 · doi:10.1128/jvi.00479-25
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Also filed as BioProject PRJNA1439312 and SRA study SRP684831. Searching any of these in the dataset finder brings you back here.

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