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Transcriptome Sequencing of BAPN-Induced Aortic Dissection in Male and Female Mice

GSE325608 Mus musculus (mouse) RNA-seq (gene expression) 48 samples Submitted 2026/07/22 Platform GPL28457
At a glance

RNA-seq (gene expression) · mouse · 48 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
48 samples: 6 conditions, mostly with about 10 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Integrated multi-omics analysis reveals a gut microbiota-tryptophan metabolism axis contributes to sex differences in a β-aminopropionitrile-induced aortic dissection mouse modelBiology of sex differences · 2026
Summary (written by the submitters)
Transcriptional profiling of thoracic aortic tissue from male and female C57BL/6J mice after aortic dissection (AD) induction via continuous β-aminopropionitrile (BAPN) administration, compared with sex-matched control mice. This study aims to investigate the sex-based differences in AD susceptibility and elucidate the molecular mechanisms underlying female resistance to AD.
Published in
Integrated multi-omics analysis reveals a gut microbiota-tryptophan metabolism axis contributes to sex differences in a β-aminopropionitrile-induced aortic dissection mouse model
Cheng S, Hao X, Liu S et al. · Biology of sex differences 2026 · PMID 42157054 · doi:10.1186/s13293-026-00925-6
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE325608_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1441253 and SRA study SRP685820. Searching any of these in the dataset finder brings you back here.

Study design
6 conditions, mostly with about 10 replicates each
MaCon ×10 FeCon ×10 FeAAD ×9 FeNonAD ×8 MaAAD ×7 MaNonAD ×4

Supports a between-group comparison across 48 samples.

How we read this: 6 replicated groups read from 48 sample titles; they account for 48 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 8 more — browse all 48 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.