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RNA-seq analysis of human NSCLC cell lines treated with 9α,11α-dihydroxy-kaurenoic acid (AL-X)

GSE325732 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/23 Platform GPL24676
Summary
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide. In this study, we performed bulk RNA sequencing to investigate the transcriptomic effects of 9α,11α-dihydroxy-kaurenoic acid (9α,11αOH-KA, also referred to as AL-X) in human NSCLC cells. A549, HCC827, and H1975 cell lines were treated with 10 μg/mL 9α,11αOH-KA or vehicle (DMSO) for 48 hours. Total RNA was extracted and subjected to paired-end sequencing using the Illumina platform. This dataset provides a comprehensive resource for understanding the molecular mechanisms underlying mitochondrial dysfunction and anti-cancer effects induced by 9α,11αOH-KA in NSCLC.
Published in
Mitochondrial oxidative phosphorylation inhibition by 9α,11α-dihydroxy-kaurenoic acid promotes ROS-associated apoptosis and suppresses cancer stemness in non-small cell lung cancer
Wu KC, Liu YC, Weng JR et al. · Scientific reports 2026 · PMID 42191811 · doi:10.1038/s41598-026-55357-4
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Also filed as BioProject PRJNA1441527 and SRA study SRP685978. Searching any of these in the dataset finder brings you back here.

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