Single-cell RNA sequencing of human hepatocellular carcinoma and adjacent non-tumour liver tissues reveals etiology-associated and etiology-independent tumour microenvironmental features

Hepatocellular carcinoma (HCC) arises in the context of diverse aetiological backgrounds, yet the extent to which the tumour microenvironment is shaped by aetiology-associated versus aetiology-independent programmes remains incompletely understood. This dataset was generated to support interrogation of the cellular architecture of human HCC and the surrounding liver microenvironment at single-cell resolution. By profiling tumour and adjacent non-tumour liver tissues, the study provides a resource for examining malignant, immune, stromal, and hepatic parenchymal cell populations, and for investigating shared and aetiology-linked features of the HCC tumour microenvironment.