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NAT10-mediated N4-acetylcytidine modification drives RNA splicing of PML to alleviate adipose-derived stem cell senescence and promote diabetic wound healing

GSE326590 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/06 Platform GPL34284
Summary
Cellular senescence in adipose-derived stem cells (ADSCs) limits their application in diabetic wounds. Alternative splicing generates multiple isoforms that play critical roles in modulating stem cell senescence. N-acetyltransferase 10 (NAT10) regulates N4-acetylcytidine (ac4C) modification, which has been implicated in RNA splicing. As the role of NAT10 in ADSCs remains elusive, this study aimed to investigate the function of NAT10 in ADSC senescence and RNA splicing.
Published in
NAT10-mediated N4-acetylcytidine modification drives RNA splicing of PML to alleviate adipose-derived stem cell senescence and promote diabetic wound healing
Wei W, Jiang C, Zhu D et al. · Clinical and translational medicine 2026 · PMID 42281170 · doi:10.1002/ctm2.70711
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Also filed as BioProject PRJNA1445971 and SRA study SRP688229. Searching any of these in the dataset finder brings you back here.

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