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Chromatin accessibility profile at single cell level of different phenotypic tumors derived from the human non-muscle invasive bladder carcinoma cell line, MGH-U3

GSE326929 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 3 samples Submitted 2026/04/07 Platform GPL24676
Summary
To understand the genetic mechanisms by which IGFBP5 regulates aggressive progression and squamous traits, we performed whole-exome sequencing (WES) on three distinct cell lines: CTR-MGH-U3-LT, UCSD-MGH-U3-LT, and MP-MGH-U3-LT. WES revealed no mutations in IGFBP5, suggesting that its regulatory role may involve epigenetic mechanisms. We next sought to perform single-cell ATAC-seq to investigate a potential epigenetic mechanism underlying IGFBP5 regulated squamous traits and aggressiveness.
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Also filed as BioProject PRJNA1435562 and SRA study SRP682782. Searching any of these in the dataset finder brings you back here.

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