A CSF Disease-Associated Macrophage Signature defines Progressive Multiple Sclerosis [Frozen]
Single-cell RNA-seq · human · 25 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 25 samples: 9 × human_CSF_RMS vs 8 × human_CSF_Ctrl vs 5 × human_CSF_PPMS vs 3 × human_CSF_SPMSGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A CSF disease-associated macrophage signature defines progressive multiple sclerosisJournal of neuroinflammation · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE327243_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1450035 and SRA study SRP689887. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 25 samples.
How we read this: 4 replicated groups read from 25 sample titles; they account for 25 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9651991 human_CSF_Ctrl_1 human_CSF_Ctrl
- GSM9651992 human_CSF_Ctrl_3 human_CSF_Ctrl
- GSM9651993 human_CSF_Ctrl_4 human_CSF_Ctrl
- GSM9651994 human_CSF_Ctrl_5 human_CSF_Ctrl
- GSM9651995 human_CSF_Ctrl_6 human_CSF_Ctrl
- GSM9651996 human_CSF_Ctrl_7 human_CSF_Ctrl
- GSM9651997 human_CSF_Ctrl_9 human_CSF_Ctrl
- GSM9651998 human_CSF_Ctrl_10 human_CSF_Ctrl
- GSM9651999 human_CSF_PPMS_1 human_CSF_PPMS
- GSM9652000 human_CSF_PPMS_2 human_CSF_PPMS
- GSM9652001 human_CSF_PPMS_3 human_CSF_PPMS
- GSM9652002 human_CSF_PPMS_4 human_CSF_PPMS
- GSM9652003 human_CSF_PPMS_5 human_CSF_PPMS
- GSM9652004 human_CSF_RMS_1 human_CSF_RMS
- GSM9652005 human_CSF_RMS_2 human_CSF_RMS
- GSM9652006 human_CSF_RMS_3 human_CSF_RMS
- GSM9652007 human_CSF_RMS_4 human_CSF_RMS
- GSM9652008 human_CSF_RMS_5 human_CSF_RMS
- GSM9652009 human_CSF_RMS_6 human_CSF_RMS
- GSM9652010 human_CSF_RMS_7 human_CSF_RMS
- GSM9652011 human_CSF_RMS_8 human_CSF_RMS
- GSM9652012 human_CSF_RMS_9 human_CSF_RMS
- GSM9652013 human_CSF_SPMS_1 human_CSF_SPMS
- GSM9652014 human_CSF_SPMS_2 human_CSF_SPMS
- GSM9652015 human_CSF_SPMS_3 human_CSF_SPMS
- GSE290554 Mapping the Molecular Signature of Progressive Multiple Sclerosis 94 samples shares progressive, signature, sclerosis, multiple
- GSE286068 CITEseq analysis of human CSF cells in Multiple sclerosis 26 samples shares csf, sclerosis, multiple
- GSE297192 Integrative single cell analysis of progressive multiple sclerosis induced neural stem cells reveals epigenetically dysregulated type-I-interferon signaling 25 samples shares progressive, sclerosis, multiple
- GSE231585 Gene expression profiling at single nucleus level of microdissected white matter tissue samples of patients with progressive multiple sclerosis and non-neurological disease controls 15 samples shares progressive, sclerosis, multiple
- GSE181946 The PKCα/ZFP64/CSF1 Axis restricts Tumor Response to Anti-PD1 by driving Macrophage M2 Polarization in Hepatocellular Carcinoma [RNA-seq 1] 17 samples shares csf, macrophage
- GSE274114 Metabolic dysfunction-associated steatohepatitis reduces interferon and macrophage liver gene signatures in chronic HBV patients 39 samples shares macrophage, signature
- GSE320020 Macrophage–Fibroblast Signaling Network Identified by Single-Cell RNA Sequencing in Juvenile Systemic Sclerosis 11 samples shares macrophage, sclerosis
- GSE270387 Single cell profiling of peripheral blood mononuclear cells in diverse men with prostate cancer reveals lethal disease-associated immune signatures 165 samples shares disease-associated, signature
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.