GEO series
Dynamin 2 regulates mitochondrial mitotic fission in pulmonary hypertension
GSE327258
Homo sapiens
Expression profiling by high throughput sequencing
10 samples
2026/05/01
GPL21697
Summary
Dynamin-related protein 1 (DRP1) mediates mitochondrial fission and permits rapid cell cycle progression in hyperproliferative cells by coordinating nuclear and mitochondrial division, a process called mitotic fission. However, DRP1 alone appears insufficient to complete fission and the link between fission and cell cycle progression is unknown.We hypothesize Dynamin 2 (DNM2) interacts with DRP1 to complete mitochondrial fission and regulate cell cycle progression. We show that DNM2 is upregulated in pulmonary arterial smooth muscle cells in human and rodent pulmonary arterial hypertension (PAH PASMC), contributing to disease pathophysiology.
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Paper (PMID 42047020) ↗
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