USP22 Suppresses Trophoblast Cell Necroptosis in Preeclampsia by Stabilizing KAT2A-Mediated Histone Acetylation at the SFRP1 Promoter
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 6 × NC vs 6 × SiRNAGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- USP22 suppresses trophoblast cell necroptosis in preeclampsia by stabilizing KAT2A-mediated histone acetylation at the SFRP1 promoterJournal of translational medicine · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE327405_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1450656 and SRA study SRP690230. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9656400 NC_1 NC
- GSM9656401 NC_2 NC
- GSM9656402 NC_3 NC
- GSM9656403 NC_4 NC
- GSM9656404 NC_5 NC
- GSM9656405 NC_6 NC
- GSM9656406 SiRNA_1 SiRNA
- GSM9656407 SiRNA_2 SiRNA
- GSM9656408 SiRNA_3 SiRNA
- GSM9656409 SiRNA_4 SiRNA
- GSM9656410 SiRNA_5 SiRNA
- GSM9656411 SiRNA_6 SiRNA
- GSE243579 iPSC-based modeling of preeclampsia identifies defects in extravillous trophoblast differentiation 144 samples shares preeclampsia, trophoblast
- GSE186257 Histopathologic and transcriptome profiling identify novel trophoblast lineage-specific defects in preeclampsia 44 samples shares preeclampsia, trophoblast
- GSE311483 BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia 32 samples shares preeclampsia, trophoblast
- GSE263305 Analysis of retroviral MLT1 enhancer-driven genes identifies over-expression of EPS8L1 as an early-stage initiator of both oxidative stress and poor trophoblast invasiveness in the pregnancy disorder preeclampsia 24 samples shares preeclampsia, trophoblast
- GSE255126 Activated PRDM1-CREBBP Axis Contributes to Apoptosis and Impaired Invasion of Trophoblasts: A Novel Mechanism Underlying Preeclampsia 10 samples shares preeclampsia, trophoblast
- GSE324111 Vascular endothelial growth factor receptors 1 and 3 mediate placental trophoblast leptin production in preeclampsia, inducing vascular dysfunction 6 samples shares preeclampsia, trophoblast
- GSE271940 FAK regulates trophoblast functions of invasion and proliferation through Rap1 pathway in preeclampsia 6 samples shares preeclampsia, trophoblast
- GSE278196 Short communication: Upregulation of hypoxia/reoxygenation-induced Shc3 by downregulated miR-455-5p, suppresses trophoblasts implantation and is associated with placental inflammation and angiogenesis of preeclampsia 6 samples shares preeclampsia, trophoblast
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.