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Evaluation of clofazimine treatment on functional gene transcription in hepatocellular carcinoma cells

GSE327600 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/04/15 Platform GPL34284
Summary
Clofazimine (CFZ) is an orally administered anti-mycobacterial drug that demonstrates a broad spectrum of activity against mycobacterial infections, including leprosy and tuberculosis. CFZ also possesses anti-inflammatory and anti-tumor properties by disrupting DNA replication and inhibiting the production of IL2. Currently, this compound has been utilized in research related to drug-resistant cancer treatment, and has gained increasing recognition for its potential to enhance cancer treatment in recent years. Considering the benefits of CFZ in clinical settings, it presents itself as a promising candidate for combination drug therapy aimed at hepatocellular carcinoma through the regulation of functional gene transcription. Herein, we primarily examine the role of CFZ treatment throughout the functional gene transcription process in hepatocellular carcinoma cells.
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Direct links to NCBI, no account and no request form: the whole study as GSE327600_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1451517 and SRA study SRP690793. Searching any of these in the dataset finder brings you back here.

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