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Using Chip-seq to analyze the distribution of XRCC5/6 on HBV DNA

GSE327675 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/04/20 Platform GPL29480
Summary
In this study, we found that XRCC5/6, as DNA-binding proteins, can bind to HBV DNA and regulate HBV transcription. To directly analyze the binding regions of XRCC5/6 on HBV DNA, ChIP-seq was performed in HepG2.2.15 cells using antibodies against XRCC5 and XRCC6. The results revealed that XRCC5/6 were abundantly distributed across the HBV genomic DNA, with significant enrichment around the HBV promoters.
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Direct links to NCBI, no account and no request form: the whole study as GSE327675_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1451841 and SRA study SRP690910. Searching any of these in the dataset finder brings you back here.

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