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ATAC-seq profiling reveals that KLF2 regulates chromatin accessibility programs in HCC

GSE328230 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/04/21 Platform GPL24676
Summary
Krüppel-like factor 2 (KLF2) is a tumor-suppressive transcription factor implicated in the regulation of epithelial-mesenchymal plasticity in hepatocellular carcinoma (HCC). In this study, we performed ATAC-seq in HCCLM3 human HCC cells with or without KLF2 overexpression to characterize KLF2-associated changes in chromatin accessibility. Comparative analysis was used to identify differentially accessible chromatin regions and to investigate how KLF2 affects the transcriptional programs associated with Hippo/YAP signaling and EMT/pEMT-related cell plasticity.
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Also filed as BioProject PRJNA1454406 and SRA study SRP692403. Searching any of these in the dataset finder brings you back here.

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