← BioTransfer GEO Dataset Finder
GEO series

The circadian clock component BMAL1 enhances macrophage inflammation by nuclear translocation of peroxisomal β-oxidation enzyme MFP2

GSE328383 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/04/29 Platform GPL34290
Summary
This study investigated how the circadian regulators BMAL1 and MFP2 control macrophage inflammatory responses through epigenetic mechanisms. Using H3K27ac ChIP‑seq, we analyzed genome‑wide histone H3 lysine 27 acetylation (H3K27ac) in wild‑type, Bmal1‑deficient, and Mfp2‑deficient RAW264.7 cells, a mouse macrophage‑like cell line. Comparative analyses revealed substantial overlap in H3K27ac regions reduced upon loss of BMAL1 or MFP2, suggesting a coordinated BMAL1–MFP2 axis in the regulation of inflammation‑associated chromatin states.
Published in
The circadian clock component BMAL1 enhances macrophage inflammation by nuclear translocation of peroxisomal β-oxidation enzyme MFP2
Tsuruta A, Hirao N, Shibata M et al. · Cell reports 2026 · PMID 42268717 · doi:10.1016/j.celrep.2026.117480
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE328383_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1454884 and SRA study SRP692748. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.