GEO series
Divergent Cytotoxic and Inflammatory Functions of Intratumoral Vd2+ gdT Cells in Renal Cell Carcinoma
GSE328705
Homo sapiens
Expression profiling by high throughput sequencing
3 samples
2026/08/06
GPL24676
Summary
We characterized Vd2+ gdT cell subsets in paired peripheral blood and tumor samples from three treatment-naive clear cell renal cell carcinoma (ccRCC) patients using flow cytometry and single-cell RNA sequencing. Two major subsets distinguished by CD16 expression exhibited divergent cytotoxic and inflammatory effector programs within the tumor microenvironment. Single-cell RNA sequencing identified four transcriptional clusters with a TOX+ progenitor-like cluster giving rise to divergent effector states.
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Paper (PMID 42539629) ↗
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