GEO series
A transparent PVA-based polymer sunscreen protects retinal tissue from ultraviolet damage
GSE329195
Homo sapiens
Expression profiling by high throughput sequencing
36 samples
2026/04/29
GPL24676
Summary
Ultraviolet (UV) light causes many eye diseases. Wearing sunglasses blocks <50% UV light from entering eyes. Skin sunscreens are banned for eye use due to irritation and safety concerns. Few sunscreens can be used in the eye to block UV light without compromising the eye functions. Herein, we modified poly(vinyl alcohol) (PVA), the active ingredient in commercial artificial tears, using naturally extracted aldehydes through Hantzsch’s reaction and obtained a PVA-syringaldehyde derivative that has a high sun protection factor (SPF 80), excellent UV resistance (>99%) and high transparency (84%) at 1 wt% in water, and a long half-life with little acute irritation and long-term safety when applied to female mouse eyes. Zebrafish protected by this polymer maintained healthy eye tissues and vision-guided behaviors after UV exposure. Polymer treatment on mice eyes effectively protected the retina from UV-induced damage, suggesting its potential as an eye sunscreen.
Download
NCBI GEO page ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
human RNA-seq datasets →
Similar datasets
- GSE328275 Single-cell RNA sequencing of CD45+ immune cells across primary tumor, sentinel tumor-draining lymph node, and axillary lymph node in treatment-naive triple-negative breast cancer 28 samples
- GSE341753 Cohesin loading at regulatory elements shapes 3D genome folding during erythropoiesis [RNA-Seq] 12 samples
- GSE319969 Spatial and Bulk Transcriptomic Profiling Defines the Molecular Evolution of Cutaneous Squamous Cell Carcinoma and Reveals Stage-Specific Biomarkers of Clinical Relevance [RNA-Seq] 24 samples
- GSE342462 Integrated transcriptomic and bioelectrical profiling of stem-like cellular states in a colorectal cancer using SdFFF and UHF-DEP 12 samples
- GSE313035 METIMMOX: Colorectal Cancer METastasis - Shaping Anti-tumor IMMunity by OXaliplatin 67 samples
- GSE339456 Integrated bulk and spatial transcriptomic analysis identifies progression-associated molecular signatures in biopsy-proven hypertensive nephropathy [RNA-seq] 35 samples
- GSE341139 A conserved HAND2-BMP5-SMAD1/5/9 axis drives hepatic stellate cell activation and extracellular matrix overproduction in multiple fibrotic etiologies 10 samples
- GSE274275 Effect of depletion of NSUN4 on gene expression of NCI-H226 cells [RNA-seq] 6 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.