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Beta-hydroxybutyrate enhances mitochondrial energy metabolism through histone beta-hydroxybutyrylation

GSE329902 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/05/09 Platform GPL24676
Summary
Beta-hydroxybutyrate (BHB) regulates gene expression through modulation of post-translational histone modifications, including histone beta-hydroxybutyrylation. In human renal tubular epithelial cells challenged with hydrogen peroxide, pretreatment with sodium beta-hydroxybutyrate (BHBNa) significantly upregulated global histone beta-hydroxybutyrylation marks, specifically enhancing beta-hydroxybutyrylation at histone H3 lysine 4 (H3K4bhb) compared to hydrogen peroxide treatment alone. To investigate whether BHB enhances mitochondrial energy metabolism via this epigenetic mechanism, we performed chromatin immunoprecipitation sequencing (ChIP-seq) specifically targeting H3K4bhb.
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Also filed as BioProject PRJNA1290643 and SRA study SRP600391. Searching any of these in the dataset finder brings you back here.

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