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Inflammatory Monocytes Constrain YAP-Induced Cell Proliferation [scRNA-seq immune]

GSE329924 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/07/01 Platform GPL34328
Summary
YAP and its paralog, TAZ are transcriptional co-activators of the Hippo pathway that regulate cell growth. Their structural distinctiveness suggests important independent functional differences. To investigate this further, we generated YAP- and TAZ-predominant clones in the liver and followed their long-term behavior. YAP clones rapidly de-differentiate cells into a stem cell-like state with inflammatory immune cell recruitment followed by their clearance. In contrast, TAZ clones promote an anti-inflammatory immune environment resulting in their long-term maintenance, massive organ growth and increased mortality. YAP clones recruit inflammatory blood-derived monocytes, which if inhibited permits YAP clonal growth. Consistent with these results, YAPHigh colorectal cancer (CRC) patients had a 67% 5-year survival rate, while TAZHigh CRC patients did not survive to 5 years. Similar trends were seen in hepatocellular carcinoma patients. These findings underscore the importance of understanding the intrinsic differences in YAP and TAZ biology as independent drivers of disease.
Published in
Inflammatory monocytes constrain YAP-induced cell proliferation
Singh S, Tahmasian N, Liu JJ et al. · Science advances 2026 · PMID 42341114 · doi:10.1126/sciadv.aee8580
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Also filed as BioProject PRJNA1462223 and SRA study SRP697609. Searching any of these in the dataset finder brings you back here.

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