GEO series
TGFβ-Dependent Epithelial–Mesenchymal Plasticity in Immortalized Human Atrial Epicardial Cells: An mRNA Profiling Study
GSE330909
Homo sapiens
Expression profiling by high throughput sequencing
15 samples
2026/07/23
GPL34284
Summary
The adult mammalian heart exhibits limited regenerative capacity, and a stable adult human in vitro model for investigating epicardial activation remain limited. Here, we isolated human epicardium-derived cells from the adult heart auricle. Successful immortalization led to the generation of a stable immortalized epicardium-derived cell (iEPDC) population, allowing the investigation of intercellular dynamics upon EMT activation. TGFβ signalling was modulated using SB431542 or TGFβ3.
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Paper (PMID 42505420) ↗
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