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Epicardial fat drives macrophage response in atrial cardiomyopathy [scRNA-Seq]

GSE331465 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/05/20 Platform GPL24247
Summary
Single-cell RNA sequencing was performed on atrial cells isolated from mice fed either normal diet (ND) or high-fat diet (HFD) for 2 or 4 months to investigate immune and stromal remodeling during obesity-associated atrial cardiomyopathy. Distinct Lyve1+ resident and CCR2+ monocyte-derived macrophage populations were identified in obese mouse atria and were associated with atrial adiposity, fibro-fatty remodeling, and atrial fibrillation progression.
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Direct links to NCBI, no account and no request form: the whole study as GSE331465_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1468190 and SRA study SRP702120. Searching any of these in the dataset finder brings you back here.

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