GEO series
Single-cell sequencing reveals NK cell dysregulation during chronic HIV infection and identifies transitional NK cell cytotoxicity related to HIV reservoir decay
GSE332837
Homo sapiens
Expression profiling by high throughput sequencing
39 samples
2026/07/22
GPL18573
Summary
We performed scRNA-seq on NK cells from HCs and PLWH before/after ART. We identified ten subsets, including IFN-responding (c7) and proliferating (c8, c9) cells that expand in untreated PLWH. Cytotoxicity of the transitional NK before ART correlated with subsequent HIV-DNA decline. Our findings reveal NK cell heterogeneity during HIV infection, informing NK-based immunotherapies.
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Paper (PMID 42475880) ↗
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