GEO series

Gene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-cre;KrasLSL-G12D;IKK2/beta F/F mice

GSE33322 Mus musculus (mouse) Expression microarray 12 samples Submitted 2012/01/24 Platform GPL6246

At a glance

Expression microarray · mouse · 12 samples

What it is: Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
Organism: Mus musculus (mouse)
Samples: 12 samples
Data you can get: A processed expression table (series matrix) and the array files, from NCBI.

Summary (written by the submitters)

Constitutive Kras and NF-kB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). Here, we report that pancreas-targeted IKK2/beta inactivation inhibited NF-kB activation and completely suppressed PDAC development. Our findings demonstrated that NF-kB is required for development of pancreatic ductal adenocarcinoma that was initiated by Kras activation.

This dataset

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Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗

3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE33322_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.

Also filed as BioProject PRJNA156643. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 22264792) ↗

Samples in this study

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+ 12 more — browse all 12 samples with per-sample file links →

Datasets on a similar topic

GSE33323 Kras-induced ikk2/nf-kappaB activation by IL-1 alpha and p62 freedforward loops is required for development of pancreatic ductal adenocarcinoma 13 samples shares ikk2, pancreatic, kras
GSE281154 mRNA transcriptome sequencing of tumor cells, TRMs, MDMs, Monocytes and CD8+ T cells from tumor lungs of KrasLSL-G12D/+Lkb1fl/fl (KL), KrasLSL-G12D/+Lkb1fl/flGpx4m/m(KLG4) after Ad-cre injection and tamoxifen treatment 17 samples shares lsl-g12d, kraslsl-g12d, kras
GSE144704 Enhancer activation during tumor progression in the KrasLSLG12D/+; Trp53LSLR172H/+; Pdx1-Cre (KPC) mouse model of pancreatic ductal adenocarcinoma. 8 samples shares pdx1-cre, pancreatic, kras
GSE306633 Limited activation interdependence, and differing patterns of the in vivo effects, of IKK1 and IKK2 downstream of NIK 24 samples shares ikk2
GSE308937 Pex5 WT vs Pdx1-cre KO Islet RNA (WT are a combination of Pex5 floxed and non floxed Cre only) 15 samples shares pdx1-cre
GSE255140 Transcriptional profiling of DLBCL-like murine pBIC10 tumors (p53F/F; Blimp1F/F; IKK2castopF/stopF; Cg1Cre/+; IL-10F/F) 10 samples shares ikk2
GSE288294 Effect of Eya3 knockdown and constitutively-active NF-kB add-back (IKK2-SE) in 66cl4 cells in vitro 9 samples shares ikk2
GSE262423 Cpt1a WT vs Pdx1-cre Islet RNA 8 samples shares pdx1-cre

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