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scRNAseq of human intestinal organoids infected with coxsackievirus B1

GSE333246 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/05/31 Platform GPL34284
Summary
We applied 10X Genomic scRNAseq to profile cell population within human intestinal organoids infected with coxsackievirus B1. The intestinal epithelium represents the first line of defense in the gastrointestinal tract, forming an essential barrier that, when compromised, renders individuals with celiac disease (CeD) susceptible to mucosal damage. By connecting viral infections and gluten challenges, this study sheds light on a mechanistic bridge between viral infection and gluten peptide modification, a critical step in the onset of CeD.
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Direct links to NCBI, no account and no request form: the whole study as GSE333246_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1470563 and SRA study SRP703690. Searching any of these in the dataset finder brings you back here.

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