GEO series
Genomic hallmarks of depot medroxyprogesterone acetate-associated meningiomas [RNA-seq]
GSE335175
Homo sapiens
Expression profiling by high throughput sequencing
10 samples
2026/06/12
GPL30173
Summary
Integrated genomic characterization of meningiomas from 10 women with long-term exposure to depot medroxyprogesterone acetate (DMPA), a commonly used injectable progestin contraceptive. All tumors were newly diagnosed WHO grade 1 meningiomas. We profiled genome-wide DNA methylation (Illumina Infinium MethylationEPIC v2.0) and performed bulk RNA sequencing on all 10 tumors, and integrated these data with public reference meningioma cohorts (Baylor, GSE189521; Heidelberg, GSE109381) for methylation classifier assignment, consensus clustering, copy-number analysis, and differential methylation testing.
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