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Differentially expressed genes (DEGs) in HEK-293T cells treated with the culture supernatant of yeast-form Candida albicans

GSE335460 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/20 Platform GPL16791
Summary
The yeast-form of Candida albicansis known to secrete bioactive metabolites that modulate host cellular responses. In this study, we investigated the transcriptional impact of yeast-form C. albicansculture supernatant on human embryonic kidney (HEK)-293T cells. HEK-293T cells were treated with the supernatant, followed by RNA sequencing (RNA-seq) to identify differentially expressed genes (DEGs). Transcriptomic profiling revealed a distinct gene expression signature in treated cells compared to controls. Functional enrichment analysis of these DEGs highlighted significant modulation of pathways associated with cellular stress responses and signal transduction. These findings provide a comprehensive genomic landscape of the host cell response to soluble factors derived from the yeast-form C. albicans, offering insights into the molecular mechanisms underlying fungus-host cell interactions at the transcriptional level.
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Also filed as BioProject PRJNA1478589 and SRA study SRP709711. Searching any of these in the dataset finder brings you back here.

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