GEO series
ARID1B loss remodels the chromatin landscape to promote sorafenib resistance in hepatocellular carcinoma
GSE335770
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
80 samples
2026/06/19
GPL34284GPL30882
Summary
CUT&RUN in HepG2 and HLF HCC cell lines mapping H3K27ac, H3K4me3, ARID1B, FOXA1, FOXA2 occupancy under sorafenib treatment and ARID1B-KO conditions. 2x2 factorial (genotype x treatment), 2 biological replicates per condition. Identifies cBAF-pioneer factor chromatin axis mediating sorafenib sensitivity. Preprint: https://doi.org/10.64898/2026.06.11.731725
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