GEO series
Transcriptomic effects of neprilysin inhibition during endothelin-1–induced hypertrophic stress in human iPSC-derived cardiomyocytes
GSE335813
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/06/22
GPL34284
Summary
Human induced pluripotent stem cell–derived cardiomyocytes were used to investigate the cardiomyocyte-intrinsic effects of neprilysin inhibition during hypertrophic stress. Cardiomyocytes were treated with endothelin-1, the neprilysin inhibitor sacubitrilat, a combination of endothelin-1 and sacubitrilat, or vehicle control. Bulk RNA sequencing was performed to characterize transcriptional remodeling induced by endothelin-1 and to determine whether neprilysin inhibition modifies this response.
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