GEO series
MTOR-dependent expression of SP1 promotes the tolerogenic function of dendritic cells by inducing IL10 expression
GSE335844
Homo sapiens
Expression profiling by high throughput sequencing
10 samples
2026/06/25
GPL24676
Summary
Dendritic cells (DCs) are central regulators of immune responses and tolerance. Although CTLA4-Ig has been reported to promote tolerogenic properties in DCs, the molecular mechanisms underlying this process remain incompletely understood. The aim of this study was to characterize the transcriptional programs associated with CTLA4-Ig-induced tolerogenic DCs. Human monocyte-derived DCs from healthy donors were stimulated with LPS in the presence of either control IgG or CTLA4-Ig and subjected to RNA sequencing. Comparative transcriptomic analysis was performed to identify differentially expressed genes and pathways associated with CTLA4-Ig-mediated tolerogenic reprogramming.
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