MTOR-dependent expression of SP1 promotes the tolerogenic function of dendritic cells by inducing IL10 expression
RNA-seq (gene expression) · human · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 10 samples: 5 × moDCs_LPS_IgG vs 5 × moDCs_LPS_CTLA4IgGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE335844_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1479698 and SRA study SRP710641. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9822001 moDCs_LPS_IgG_1 moDCs_LPS_IgG
- GSM9822002 moDCs_LPS_CTLA4Ig_1 moDCs_LPS_CTLA4Ig
- GSM9822003 moDCs_LPS_IgG_2 moDCs_LPS_IgG
- GSM9822004 moDCs_LPS_CTLA4Ig_2 moDCs_LPS_CTLA4Ig
- GSM9822005 moDCs_LPS_IgG_3 moDCs_LPS_IgG
- GSM9822006 moDCs_LPS_CTLA4Ig_3 moDCs_LPS_CTLA4Ig
- GSM9822007 moDCs_LPS_IgG_4 moDCs_LPS_IgG
- GSM9822008 moDCs_LPS_CTLA4Ig_4 moDCs_LPS_CTLA4Ig
- GSM9822009 moDCs_LPS_IgG_5 moDCs_LPS_IgG
- GSM9822010 moDCs_LPS_CTLA4Ig_5 moDCs_LPS_CTLA4Ig
- GSE294526 The USP11/TCEAL1 complex promotes transcription elongation to sustain oncogenic gene expression in neuroblastoma [RNA-seq II] 21 samples shares sp1, promotes
- GSE305053 mtROS-driven Sp1-dependent retrograde signaling promotes colorectal tumor progression via SIRT3-PAGM5 axis-governed mitochondrial homeostasis 8 samples shares sp1, promotes
- GSE268124 USP11 promotes prostate cancer progression by upregulating AR and c-Myc activity [RNA-seq] 6 samples shares sp1, promotes
- GSE312505 The deubiquitinase USP1 promotes the progression of AML by stabilizing ID1 [RNAseq_AML_shUSP1] 4 samples shares sp1, promotes
- GSE326894 The HSF2-HSP110 Axis Promotes Genome Stability by Supporting RNA Polymerase II Dependent Transcription and DNA Repair Gene Expression [CUT&Run] 15 samples shares sp1, promotes
- GSE294527 The USP11/TCEAL1 complex promotes transcription elongation to sustain oncogenic gene expression in neuroblastoma [ChIP-seq II] 10 samples shares sp1, promotes
- GSE268252 USP11 promotes prostate cancer progression by upregulating AR and c-Myc activity [CUT&RUN] 26 samples shares sp1, promotes
- GSE312506 The deubiquitinase USP1 promotes the progression of AML by stabilizing ID1 [ID1 CUT&Tag in AML] 4 samples shares sp1, promotes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.