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DUSP5 regulates ferroptosis in pancreatic cancer by down-regulating SCD1 expression via ERK1/2

GSE336205 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/28 Platform GPL24676
Summary
This study aimed to explore the role and mechanism of DUSP5 in pancreatic ductal adenocarcinoma (PDAC). RNA sequencing was performed in DUSP5-overexpressing PANC-1 cells and control cells to identify differentially expressed genes. The results revealed that DUSP5 significantly downregulated stearoyl-CoA desaturase 1 (SCD1), a key enzyme involved in fatty acid metabolism and ferroptosis regulation. Our findings indicate that DUSP5 promotes ferroptosis and suppresses PDAC proliferation through the ERK1/2-SCD1 signaling pathway.
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Also filed as BioProject PRJNA1481063 and SRA study SRP711773. Searching any of these in the dataset finder brings you back here.

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