Reciprocal, methylation-dependent binding of Zfp57 and Gzf1 safeguards Dlk1-Dio3 imprinting during developmental reprogramming
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 64 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 64 samples: 50 distinct titles, 6 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE337304_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1484683 and SRA study SRP713955. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 14 samples read as cases, 22 as controls.
How we read this: Read from 64 sample titles: 50 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9848740 IG-CGI (IG-DMR) methylation, wild type, mESC
- GSM9848741 IG-CGI (IG-DMR) methylation, Gzf1 knockout, mESC
- GSM9848742 IG-CGI (IG-DMR) methylation, Dnmt1 knockout, mESC
- GSM9848743 IG-CGI (IG-DMR) methylation, Tet triple knockout, mESC
- GSM9848744 IG-CGI (IG-DMR) methylation, wild type (RGM reporter), mESC reporter
- GSM9848745 IG-CGI (IG-DMR) methylation, Zfp57 knockout (RGM reporter), mESC reporter
- GSM9848746 IG-CGI (IG-DMR) methylation, Zfp57/Gzf1 double knockout (RGM reporter), mESC reporter
- GSM9848747 IG-TRE methylation, wild type, mESC
- GSM9848748 IG-TRE methylation, Gzf1 knockout, mESC
- GSM9848749 Gtl2-DMR methylation, wild type, mESC
- GSM9848750 Gtl2-DMR methylation, Gzf1 knockout, mESC
- GSM9848751 IG-CGI (IG-DMR) methylation, wild type, E10.5 embryo trunk
- GSM9848752 IG-CGI (IG-DMR) methylation, Gzf1 knockout, E10.5 embryo trunk
- GSM9848753 Gtl2-DMR methylation, wild type, E10.5 embryo trunk
- GSM9848754 Gtl2-DMR methylation, Gzf1 knockout, E10.5 embryo trunk
- GSM9848755 IG-TRE methylation, wild type, E10.5 embryo trunk
- GSM9848756 IG-TRE methylation, Gzf1 knockout, E10.5 embryo trunk
- GSM9848757 IG-CGI (IG-DMR) methylation, wild type, MII oocyte
- GSM9848758 IG-CGI (IG-DMR) methylation, Gzf1 knockout, MII oocyte rep 1
- GSM9848759 IG-CGI (IG-DMR) methylation, Gzf1 knockout, MII oocyte rep 2
- GSM9848760 IG-CGI (IG-DMR) methylation, wildtype, adult mouse
- GSM9848761 IG-CGI (IG-DMR) methylation, Gzf1 knockout, adult mouse
- GSM9848762 Gtl2-DMR methylation, wild type, adult mouse
- GSM9848763 Gtl2-DMR methylation, wild type, Gzf1 knockout, adult mouse
- GSM9848764 IG-CGI (IG-DMR) methylation, Gzf1 knockout, dead pup upon birth
- GSM9848765 IG-CGI (IG-DMR) methylation, heterozygous (maternal Gzf1-KO), adult mouse 1
- GSM9848766 IG-CGI (IG-DMR) methylation, heterozygous (maternal Gzf1-KO), adult mouse 2
- GSM9848767 IG-CGI (IG-DMR) methylation, heterozygous (maternal Gzf1-KO), adult mouse 3
- GSM9848768 IG-CGI (IG-DMR) methylation, heterozygous (maternal Gzf1-KO), adult mouse 4
- GSM9848769 IG-CGI (IG-DMR) methylation, heterozygous (maternal Gzf1-KO), adult mouse 5
- GSM9848772 CRISPR screen Exp1: unsorted, 2 passages post-selection (T1, baseline)
- GSM9848773 CRISPR screen Exp1: sorted Tom+GFP- (PM, FACS control), P6
- GSM9848774 CRISPR screen Exp1: unsorted (US), P6
- GSM9848775 CRISPR screen Exp1: sorted Tom-GFP- (MM), P6
- GSM9848776 CRISPR screen Exp1: sorted Tom+GFP+ (PP, enriched fraction), P6
- GSM9848777 CRISPR screen Exp2: unsorted (US, rep1), P6
- GSM9848778 CRISPR screen Exp2: unsorted (US, rep2), P6
- GSM9848779 CRISPR screen Exp2: sorted Tom+GFP- (PM, FACS control, rep1), P6
- GSM9848780 CRISPR screen Exp2: sorted Tom+GFP- (PM, FACS control, rep2), P6
- GSM9848781 CRISPR screen Exp2: sorted Tom+GFP+ (PP, enriched fraction), P6
+ 24 more — browse all 64 samples with per-sample file links →
- GSE248780 ZFP57 is a regulator of postnatal growth and life-long health 120 samples shares zfp57
- GSE272974 The Dlk1-Dio3 noncoding RNA cluster coordinately regulates mitochondrial respiration and chromatin structure to establish proper cell state for muscle differentiation 30 samples shares dlk1-dio3
- GSE268482 The Dlk1-Dio3 noncoding RNA cluster coordinately regulates mitochondrial respiration and chromatin structure to establish proper cell state for muscle differentiation 18 samples shares dlk1-dio3
- GSE284208 The Dlk1-Dio3 noncoding RNA cluster coordinately regulates mitochondrial respiration and chromatin structure to establish proper cell state for muscle differentiation [ATAC-Seq] 16 samples shares dlk1-dio3
- GSE274171 Silencing of maternally expressed RNAs in Dlk1-Dio3 domain is critical for embryonic development 8 samples shares dlk1-dio3
- GSE299942 CBX7 functions as a methylation-dependent inducer of gene transcription and regulator of cytosolic signaling in lymphoid cells 8 samples shares methylation-dependent
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.