USP22 is a novel vulnerability regulating MEIS1 protein abundance and gene transcription in KMT2Ar acute leukemia
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 10 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 10 samples: 2 × MV411_MEIS1-ChIP vs 2 × MV411_USP22-ChIP vs 2 × SEM_MEIS1-ChIP vs 2 × SEM_USP22-ChIPGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE337426_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1485081 and SRA study SRP714795. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 4 replicated groups read from 10 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9855131 MV411_input
- GSM9855132 MV411_MEIS1-ChIP_rep1 MV411_MEIS1-ChIP
- GSM9855133 MV411_MEIS1-ChIP_rep2 MV411_MEIS1-ChIP
- GSM9855134 MV411_USP22-ChIP_rep1 MV411_USP22-ChIP
- GSM9855135 MV411_USP22-ChIP_rep2 MV411_USP22-ChIP
- GSM9855136 SEM_input
- GSM9855137 SEM_MEIS1-ChIP_rep1 SEM_MEIS1-ChIP
- GSM9855138 SEM_MEIS1-ChIP_rep2 SEM_MEIS1-ChIP
- GSM9855139 SEM_USP22-ChIP_rep1 SEM_USP22-ChIP
- GSM9855140 SEM_USP22-ChIP_rep2 SEM_USP22-ChIP
- GSE242963 The neuronal homeobox transcription factor HMX3 is a crucial vulnerability in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia 16 samples shares vulnerability, transcription, leukemia
- GSE302076 The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high MYC malignancies [ChIP-Seq] 45 samples shares vulnerability, transcription
- GSE302078 The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high MYC malignancies 56 samples shares vulnerability, transcription
- GSE280973 Transcriptional Regulation of Protein Synthesis by Mediator Kinase Represents a Therapeutic Vulnerability in MYC-driven Medulloblastoma 20 samples shares vulnerability, transcription
- GSE327563 Mediator kinase inhibition exposes a transcriptional vulnerability and primes AML for venetoclax sensitivity 18 samples shares vulnerability, transcription
- GSE305485 Cell cycle regulator MYBL2 is a distinct vulnerability in acute myeloid leukemia 12 samples shares vulnerability, leukemia
- GSE274462 ACSL4-Associated Lipid Metabolism is a Distinct Therapeutic Vulnerability in KMT2A-Rearranged Acute Myeloid Leukemia 12 samples shares vulnerability, leukemia
- GSE289452 ABL Kinase Inactivation Promotes Transcription-Replication Conflicts and Compromises Replication Forks Revealing a Therapeutic Vulnerability in Metastatic Small Cell Lung Cancer 6 samples shares vulnerability, transcription
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.