GEO series
Transcriptome analysis of tumor tissues dervied from lung cancer patients
GSE337540
Homo sapiens
Expression profiling by high throughput sequencing
22 samples
2026/07/05
GPL30209
Summary
The prognosis of non-small cell lung cancer (NSCLC) with leptomeningeal metastases (LM) is dismal. The regulators of LM progression remain elusive, thus impeding effective clinical intervention. Here, we performed transcriptome analysis of the molecular features of tumor tissues dervied from leptomeningeal-metastatic lung cancer patients. In patients with NSCLC, FUS downregulation and CD36 or SYP upregulation were associated with aggressive LM progression. CD36-mediated fatty acid metabolism and NED signature are crucial for LM progression in NSCLC, highlighting CD36 as a potential LM biomarker and a promising therapeutic target for LM treatment.
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