GEO series
A novel self-organizing embryonic stem cell system reveals the role of Wnt signaling parameters in anterior-posterior patterning of the nervous system
GSE337980
Homo sapiens
Expression profiling by high throughput sequencing
8 samples
2026/07/15
GPL34284
Summary
We performed bulk RNA sequencing of cells that are under neural induction with the WNT3A ligand added at 34 hours to induce posterior neural fates. We observed a sequential order of gene activation, from Wnt target genes to WNT8A and then to HOX genes, suggesting that WNT8A acts downstream of the Wnt signaling pathway and upstream of posterior fate markers.
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