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Genome-wide H3K27ac profiling of RAW264.7 macrophages treated with LPS and CCS1477

GSE338158 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/07/14 Platform GPL24247
Summary
Histone H3 lysine 27 acetylation (H3K27ac) ChIP-seq was performed to investigate genome-wide epigenetic changes in RAW264.7 macrophages following inflammatory stimulation and EP300 inhibition. RAW264.7 macrophages were pretreated with the EP300 inhibitor CCS1477 for 2 hours and subsequently stimulated with lipopolysaccharide (LPS) in the presence or absence of CCS1477 for 6 hours before chromatin immunoprecipitation and sequencing. Genome-wide H3K27ac occupancy was analyzed to characterize changes in chromatin activation associated with inflammatory responses and EP300 inhibition.
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Direct links to NCBI, no account and no request form: the whole study as GSE338158_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1490055 and SRA study SRP715282. Searching any of these in the dataset finder brings you back here.

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