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Immune architecture of the colon in ICI-mediated colitis compared with ulcerative colitis

GSE338317 Homo sapiens Expression profiling by high throughput sequencing 9 samples 2026/08/01 GPL18573
Summary
Despite clinical success of immune checkpoint inhibitors (ICI), many cancer patients experience immune-related adverse events (irAEs). Among these, ICI-mediated colitis (IC) is prevalent and is associated with a significant burden on patients and healthcare. Despite resemblance to ulcerative colitis (UC) with respect to clinical symptoms and treatment approaches, IC’s specific causes and cellular mechanisms are incompletely understood.
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