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Clinical and Single-Cell Sequencing Characteristics of Adult-Onset Intestinal Hypoganglionosis

GSE338463 Homo sapiens Expression profiling by high throughput sequencing 3 samples Submitted 2026/08/01 Platform GPL34284
Summary
Hypoganglionosisis a rare motility disorder characterized by a significant reduction in enteric ganglion cells.scRNA-seq indicated immune microenvironment remodeling in the lesioned bowel segment, characterized by an increased proportion of plasma cells. These plasma cells exhibited features of endoplasmic reticulum stress, activation of the unfolded protein response pathway, and enrichment in immune regulatory functions. B cells and T cells also showed enrichment in immune-related pathways.
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Direct links to NCBI, no account and no request form: the whole study as GSE338463_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 3 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1494519 and SRA study SRP717649. Searching any of these in the dataset finder brings you back here.

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