MYCN sustains a progenitor-stage differentiation block in human neuroepithelial stem cells to drive ETMR-like tumourigenesis.
Non-coding RNA profiling · human · 24 samples
- What it is
- Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples: 16 distinct titles, 3 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE339375_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
Also filed as BioProject PRJNA1498534 and SRA study SRP717862. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 24 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9876666 NESt tumour scRNA-seq, MYCN(T58A) induced in vivo, three reps
- GSM9894438 NES cells, MYCN(T58A) induced (dox), rep 1
- GSM9894439 NES cells, MYCN(T58A) induced (dox), rep 2
- GSM9894440 NES cells, MYCN(T58A) induced (dox), rep 3
- GSM9894441 NES cells, MYCN(T58A) uninduced (dox), rep 1
- GSM9894442 NES cells, MYCN(T58A) uninduced (dox), rep 2
- GSM9894443 NES cells, MYCN(T58A) uninduced (dox), rep 3
- GSM9894444 NES tumours derived from inducing MYCN(T58A) in vivo, rep 1
- GSM9894445 NES tumours derived from inducing MYCN(T58A) in vivo, rep 2
- GSM9894446 NES tumours derived from inducing MYCN(T58A) in vivo, rep 3
- GSM9894447 NES tumours derived from inducing MYCN(T58A) in vivo, rep 4
- GSM9894448 NES tumours derived from inducing MYCN(T58A) in vivo, rep 5
- GSM9894449 353486A
- GSM9894450 353486B
- GSM9894451 353486C
- GSM9894452 353490A
- GSM9894453 353490B
- GSM9894454 353490C
- GSM9894455 NESMYCNT58ADOXplusA
- GSM9894456 NESMYCNT58ADOXplusB
- GSM9894457 NESMYCNT58ADOXplusC
- GSM9894458 NESMYCNT58ADOXminusA
- GSM9894459 NESMYCNT58ADOXminusB
- GSM9894460 NESMYCNT58ADOXminusC
- GSE339373 MYCN sustains a progenitor-stage differentiation block in human neuroepithelial stem cells to drive ETMR-like tumourigenesis [RNA-seq] 11 samples shares mycn, progenitor-stage, neuroepithelial, tumourigenesis, etmr-like, sustains, block, drive
- GSE338545 MYCN sustains a progenitor-stage differentiation block in human neuroepithelial stem cells to drive ETMR-like tumourigenesis [scRNA-seq] 1 samples shares mycn, progenitor-stage, neuroepithelial, tumourigenesis, etmr-like, sustains, block, drive
- GSE268136 MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma II 82 samples shares mycn, drive
- GSE244473 METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma 55 samples shares mycn, drive
- GSE62726 Targeting of Super-Enhancer-Associated Oncogenic Transcription in MYCN-driven tumor cells by CDK7 inhibition 46 samples shares mycn, drive
- GSE164455 KDM4 inhibition disrupts the core regulatory transcriptional circuitry in MYCN-driven neuroblastoma [RNA-seq] 33 samples shares mycn, drive
- GSE62724 Targeting of Super-Enhancer-Associated Oncogenic Transcription in MYCN-driven tumor cells by CDK7 inhibition [Gene Expression] 28 samples shares mycn, drive
- GSE255593 A novel role for Neurog2 in MYCN driven neuroendocrine plasticity of prostate cancer 20 samples shares mycn, drive
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.