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MAOA+ CAFs enforce immune exclusion in pancreatic cancer by restraining serotonin-dependent histone H3Q5 serotonylation

GSE341834 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/29 Platform GPL24247
Summary
Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense desmoplasia and profound T-cell exclusion, yet the stromal metabolic programs that sustain this immune-refractory microenvironment remain poorly understood. Monoamine oxidase A (MAOA) is a mitochondrial enzyme that catalyzes serotonin degradation, but whether this metabolic pathway is co-opted by cancer-associated fibroblasts (CAFs) to regulate antitumor immunity remains unknown.
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Also filed as BioProject PRJNA1504281 and SRA study SRP722462. Searching any of these in the dataset finder brings you back here.

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