GEO series
APE1-Mediated Transcriptional Reprogramming in Esophageal Adenocarcinoma Cells under Acidic Bile Reflux Stress
GSE342322
Homo sapiens
Expression profiling by high throughput sequencing
36 samples
2026/08/06
GPL24676
Summary
Esophageal adenocarcinoma (EAC) arises in the setting of Barrett's esophagus, an intestinal metaplastic precursor lesion that can develop in patients with chronic Gastroesophageal reflux disease (GERD). This study investigates the genome-wide transcriptional adaptations and molecular stress responses mediated by Apurinic/apyrimidinic endonuclease 1 (APE1) in EAC cells under reflux-induced stress. By utilizing APE1 genetic silencing alongside exposure to an acidic bile salt (ABS), this dataset defines the global differential gene expression profiles, altered signaling pathways, and transcriptional networks that depend on APE1 for survival during reflux stress.
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