Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF
Expression microarray · human · 6 samples
- What it is
- Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
- Organism
- Homo sapiens (human)
- Samples
- 6 samples: 3 × BRAF(V600E) engineered melanomas vs 3 × BRAF(V600E)+MITF engineered melanomasGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need.
Whole study · RAW.tar
Everything the authors deposited as one archive (GSE38007_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.
What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.
Also filed as BioProject PRJNA167038. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 6 samples.
How we read this: 2 replicated groups read from 6 sample titles; they account for 6 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM931776 BRAF(V600E) engineered melanomas replicate 1 BRAF(V600E) engineered …
- GSM931777 BRAF(V600E) engineered melanomas replicate 2 BRAF(V600E) engineered …
- GSM931778 BRAF(V600E) engineered melanomas replicate 3 BRAF(V600E) engineered …
- GSM931779 BRAF(V600E)+MITF engineered melanomas replicate 1 BRAF(V600E)+MITF engine…
- GSM931780 BRAF(V600E)+MITF engineered melanomas replicate 2 BRAF(V600E)+MITF engine…
- GSM931781 BRAF(V600E)+MITF engineered melanomas replicate 3 BRAF(V600E)+MITF engine…
- GSE252781 Temporal dynamics of signaling and transcription underlying early adaptation to oncogenic BRAF inhibition in melanoma 13 samples shares braf, oncogenic
- GSE308451 CDK4/6 and SHP2 mediate BRAF/MEK inhibitor resistance in Class 2 and 3 BRAF mutant cancers 90 samples shares braf
- GSE268207 Gene expression profile of Radiatiom resistant BRAFV400E type pediatric low-grade gliomas 60 samples shares braf
- GSE298507 Inhibition of BCL2 family proteins overcomes acquired resistance to standard of care BRAF and MEK inhibitors in a subset of BRAFV600E-mutant melanomas 58 samples shares braf
- GSE273815 Melanoma plasticity is regulated by mTOR-mediated crosstalk between MITF and TFE3 56 samples shares mitf
- GSE302921 Phase I/II trial of encorafenib, cetuximab, and nivolumab in microsatellite stable, BRAFV600E metastatic colorectal cancer [dataset 1] 50 samples shares braf
- GSE255541 Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition 45 samples shares braf
- GSE280280 Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory circuits During Response to MAPK Inhibition in BRAF-mutant colorectal cancer 36 samples shares braf
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.